Application of BαM

Bio-Active Molecules(BαM) Therapy  is a holistic therapy based on super-physiological concentration of growth factors, to regulate host cell migration, proliferation, and differentiation, thus reaching the results of tissue repairment.

The application of PRP (the predecessor of BaM) was early showed up in “A new technique for hemodilution, preparation of autologous platelet-rich plasma and intraoperative blood salvage in cardiac surgery.” which published by M. Ferrari in 1987. Afterward the Clinical application of PRP start to flourish.

  • Do you know？

The nomenclature of PRP originates from the field of transfusion medicine and is classified under platelet separation techniques as PRP (Platelet-Rich Plasma Method). Platelet separation techniques also encompass the Buffy Coat Method, which involves the separation of the buffy coat layer in blood plasma.

Application of BαM

Bio-Active Molecules(BαM) Therapy  is a holistic therapy based on super-physiological concentration of growth factors, to regulate host cell migration, proliferation, and differentiation, thus reaching the results of tissue repairment.

The application of PRP (the predecessor of BaM) was early showed up in “A new technique for hemodilution, preparation of autologous platelet-rich plasma and intraoperative blood salvage in cardiac surgery.” which published by M. Ferrari in 1987. Afterward the Clinical application of PRP start to flourish.

  • DO YOU KNOW ?

The nomenclature of PRP originates from the field of transfusion medicine and is classified under platelet separation techniques as PRP (Platelet-Rich Plasma Method). Platelet separation techniques also encompass the Buffy Coat Method, which involves the separation of the buffy coat layer in blood plasma.

Tissue-Healing

Bioactive Molecular (BaM) involves centrifugation of autologous blood to separate and extract the plasma and buffy coat portion of the blood, which contain high concentrations of platelets and Leukocytes.

The platelets represent an easily accessible reservoir of critical GFs and other signaling molecules, including leukocyte-derived catabolic cytokines and fibrinogen, which may govern and regulate the tissue-healing process.

Tissue-Healing

Bioactive Molecular (BaM) involves centrifugation of autologous blood to separate and extract the plasma and buffy coat portion of the blood, which contain high concentrations of platelets and Leukocytes.

The platelets represent an easily accessible reservoir of critical GFs and other signaling molecules, including leukocyte-derived catabolic cytokines and fibrinogen, which may govern and regulate the tissue-healing process.

The effectiveness of BαM？

During the BaM therapy, patients often say that the affected area has not improved  significantly after treatment. Part of the reason may come from the ingredients of BaM. It can be divided into the following points:

The effectiveness of BαM？

During the BaM therapy, patients often say that the affected area has not improved  significantly after treatment.
Part of the reason may come from the ingredients of BaM. It can be divided into the following points:

The activity of platelets

Platelets themselves contain a substantial amount of growth factors, each with distinct roles in tissue repair. Nevertheless, current research indicates that higher concentrations of growth factors do not necessarily correlate with greater effectiveness in tissue repair. The difficulty in establishing the regulatory mechanisms of growth factor concentrations underscores the significance of maintaining platelet activity as a focal point in Platelet-Rich Plasma (PRP) therapy. Platelets have the capability to receive biological signals from damaged tissues via their receptors, thereby influencing the required amount of growth factor release. Apart from their role as providers of growth factors, platelets also play a pivotal role in regulating tissue regeneration mechanisms. Therefore, when collecting PRP, it is essential to be attentive to several factors that may trigger platelet activation:

The Activity of Platelets

Platelets themselves contain a substantial amount of growth factors, each with distinct roles in tissue repair. Nevertheless, current research indicates that higher concentrations of growth factors do not necessarily correlate with greater effectiveness in tissue repair. The difficulty in establishing the regulatory mechanisms of growth factor concentrations underscores the significance of maintaining platelet activity as a focal point in Platelet-Rich Plasma (PRP) therapy. Platelets have the capability to receive biological signals from damaged tissues via their receptors, thereby influencing the required amount of growth factor release. Apart from their role as providers of growth factors, platelets also play a pivotal role in regulating tissue regeneration mechanisms. Therefore, when collecting PRP, it is essential to be attentive to several factors that may trigger platelet activation:

TIME

MECHANICAL DAMAGE

BIOLOGICAL MECHANISM

The active secretion of these growth factors (70%) is initiated by the clotting process of blood and begins within 10 minutes after clotting. More than 95% of the pre-synthesized growth factors are secreted within 1 hour.

During the collection process of BaM, platelets may become activated and release growth factors indiscriminately due to mechanical damage,if we didn’t provid adequate space. The use of needles with smaller puncture holes for blood collection can also trigger platelet activation.

The biological signals released after platelet rupture lead to platelet aggregation, the process that prevents platelets from releasing growth factors.

TIME

The active secretion of these growth factors (70%) is initiated by the clotting process of blood and begins within 10 minutes after clotting. More than 95% of the pre-synthesized growth factors are secreted within 1 hour.

MECHANICAL DAMAGE

During the collection process of BaM, platelets may become activated and release growth factors indiscriminately due to mechanical damage,if we didn’t provid adequate space. The use of needles with smaller puncture holes for blood collection can also trigger platelet activation.

BIOLOGICAL MECHANISM

The biological signals released after platelet rupture lead to platelet aggregation, the process that prevents platelets from releasing growth factors.

The relevance between tissue regeneration and other blood cells

In the process of tissue regeneration, besides the pivotal role of platelets, other blood cells are indispensable too. Clinical research has confirmed that red blood cells not only enhance the release of α-granules (rich in growth factors) from platelets but also facilitate the conversion of ADP into ATP,providing a greater energy source for tissue regeneration. Additionally, various types of white blood cells are regulated by platelets, with monocytes, in particular, not only modulating inflammatory responses but also creating a conducive biological environment for tissue regeneration. Importantly, monocytes serve as a significant source of growth factors required in the subsequent tissue regeneration process, promoting the eventual growth of tissues into normal physiological structures. The absence of monocytes in tissue repair may lead to pathological fibrosis in the tissues.

The Relevance Between Tissue Regeneration and Other Blood Cells

In the process of tissue regeneration, besides the pivotal role of platelets, other blood cells are indispensable too. Clinical research has confirmed that red blood cells not only enhance the release of α-granules (rich in growth factors) from platelets but also facilitate the conversion of ADP into ATP,providing a greater energy source for tissue regeneration. Additionally, various types of white blood cells are regulated by platelets, with monocytes, in particular, not only modulating inflammatory responses but also creating a conducive biological environment for tissue regeneration. Importantly, monocytes serve as a significant source of growth factors required in the subsequent tissue regeneration process, promoting the eventual growth of tissues into normal physiological structures. The absence of monocytes in tissue repair may lead to pathological fibrosis in the tissues.

In summary, while there is no standardized preparation method and usage protocol for PRP, over time and with accumulating research, there has been a growing, comprehensive understanding that redefines PRP therapy as a more precise “biologically active factor therapy.” Biologically active factor therapy is a cocktail treatment where various blood cell types in the bloodstream play unique and irreplaceable roles in tissue regeneration and anti-inflammatory responses. BaM therapy aims to enhance the proportion of platelets, allowing the critical role in tissue regeneration to amplify the signals for tissue repair more effectively, thereby facilitating other blood cell types to fulfill their functions and enhance the efficiency of tissue repair.

In summary, while there is no standardized preparation method and usage protocol for PRP, over time and with accumulating research, there has been a growing, comprehensive understanding that redefines PRP therapy as a more precise “biologically active factor therapy.” Biologically active factor therapy is a cocktail treatment where various blood cell types in the bloodstream play unique and irreplaceable roles in tissue regeneration and anti-inflammatory responses. BaM therapy aims to enhance the proportion of platelets, allowing the critical role in tissue regeneration to amplify the signals for tissue repair more effectively, thereby facilitating other blood cell types to fulfill their functions and enhance the efficiency of tissue repair.

Products

Rhea Autologous Bio-active Molecules Enrich System

Phoenix Autologous Bio-active Molecules Enrich System

Products

Rhea Autologous Bio-active Molecules Enrich System

Phoenix Autologous Bio-active Molecules Enrich System

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