What is blood components ?

The composition of blood consists of red blood cells, white blood cells, platelets, and plasma. During the process of blood transfusion, clinical practice seldom transfuse whole blood; instead, blood components are administered based on the specific needs of the patients, to increase blood product utilization.

Here are some common blood products：WB(Whole Blood),PRBC(Packed Red Blood Cell),PC(Platelet Concentrates),and FFP(Fresh Frozen Plasma).

What is blood component?

The composition of blood consists of red blood cells, white blood cells, platelets, and plasma. During the process of blood transfusion, clinical practice seldom transfuse whole blood; instead, blood components are administered based on the specific needs of the patients, to increase blood product utilization.

Here are some common blood products：WB(Whole Blood),PRBC(Packed Red Blood Cell),PC(Platelet Concentrates),and FFP(Fresh Frozen Plasma).

The benefits of Leuko-reduction

Transfusion is a common but high-risk medical procedure, and many common transfusion reactions are primarily caused by white blood cells or white blood cell-derived cytokines and chemokines. There are approximately 1-3×10^9 white blood cells in 500ml of whole blood. Only when we reduce the white blood cells down to 5×10^6 can we effectively prevents transfusion reactions. These blood products, which have had white blood cells removed, are known as leukoreduced red blood cells/platelets. There are several following advantages:

  1. Preventing Febrile Nonhemolytic Transfusion Reactions (FNHTR)
  2. Preventing or delaying alloimmunization to HLA, especially in cases of ineffective platelet transfusion
  3. Preventing the transmission of congenital cytomegalovirus (CMV) in high-risk populations
  4. Reducing post-transfusion complications in patients, shortening the course of illness, and thereby decreasing healthcare costs.

The benefits of Leuko-reduction

Transfusion is a common but high-risk medical procedure, and many common transfusion reactions are primarily caused by white blood cells or white blood cell-derived cytokines and chemokines. There are approximately 1-3×10^9 white blood cells in 500ml of whole blood. Only when we reduce the white blood cells down to 5×10^6 can we effectively prevents transfusion reactions. These blood products, which have had white blood cells removed, are known as leukoreduced red blood cells/platelets. There are several following advantages:

  1. Preventing Febrile Nonhemolytic Transfusion Reactions (FNHTR)
  2. Preventing or delaying alloimmunization to HLA, especially in cases of ineffective platelet transfusion
  3. Preventing the transmission of congenital cytomegalovirus (CMV) in high-risk populations
  4. Reducing post-transfusion complications in patients, shortening the course of illness, and thereby decreasing healthcare costs.

Variety of Leuko-reduction

Depending on the timing and location of white blood cell removal, it can be categorized into pre-storage leukoreduction, blood bank leukoreduction, and bedside leukoreduction.

Variety of Leuko-reduction

Depending on the timing and location of white blood cell removal, it can be categorized into pre-storage leukoreduction, blood bank leukoreduction, and bedside leukoreduction.

Pre-storage

Laboratory

Bedside

Filtered by the blood donation center. Removing white blood cells within 8 hours after donation.

Advantages

– Easy to standardize and quality control.
– Preventing the cytokines and chemokines produced by white blood cells after storage.
-Blood product preparation is carried out in controlled environments, so it can still have a shelf life of 35 days even after filtration.

Filtered by hospital and provided for clinical transfusion.

Advantages

-Partial quality control can be achieved.

Disadvantages

-Filtered blood products cannot be stored and must be used immediately. This may also affect the timing of patient transfusions due to the processing time.

Filtering and transfusing simultaneously at the bedside.

Advantages

-Can choose whether to do leukoreduction based on the patient’s condition,and partially mitigate FNHTR.

Disadvantages

-Cannot remove the cytokines and chemokines produced by blood products after storage.

Pre-storage

Filtered by the blood donation center. Removing white blood cells within 8 hours after donation.

Advantages

– Easy to standardize and quality control.
– Preventing the cytokines and chemokines produced by white blood cells after storage.
-Blood product preparation is carried out in controlled environments, so it can still have a shelf life of 35 days even after filtration.

Laboratory

Filtered by hospital and provided for clinical transfusion.

Advantages

-Partial quality control can be achieved.

Disadvantages

-Filtered blood products cannot be stored and must be used immediately. This may also affect the timing of patient transfusions due to the processing time.

Bedside

Filtering and transfusing simultaneously at the bedside.

Advantages

-Can choose whether to do leukoreduction based on the patient’s condition,and partially mitigate FNHTR.

Disadvantages

-Cannot remove the cytokines and chemokines produced by blood products after storage.

Products

For Platelet

For Whole Blood & Red Blood Cell

Safetran AIMA bloodbag system

Products

For Platelet

For Whole Blood & Red Blood Cell

Safetran AIMA bloodbag system

© Copyright - Safetran BioMedical Inc.